Chemical Properties
White Solid
Uses
Haemostatic / Anti Coagulant
Uses
Hemostatic;prostaglandin synthesis inhibitor
Definition
ChEBI: Etamsylate is a sulfonic acid derivative and an organosulfur compound.
Biological Activity
Etamsylate is a haemostatic agent th at is used for the management of blood loss. Apparently etamsylate increases capillary wall resistance and platelet adhesives by inhibition of the biosynthesis of prostaglandins causing platelet disaggregation in a presence of vascular wound. Recent studies suggest th at etamsylate antagonizes anti-coagulant activity of heparin.
Mechanism of action
Etamsylate is an antihaemorrhagic and vasoprotective agent. It increases platelet adhesiveness and capillary vascular wall resistance, thereby reducing capillary exudation and blood loss.
Clinical Use
Short-term treatment of blood loss in menorrhagiaProphylaxis of surgical bleeding (unlicensed)
Side effects
Significant: Hypotension (parenteral). Rarely, severe hypersensitivity reaction, including anaphylaxis.
Blood and lymphatic system disorders: Parenteral: Rarely, neutropenia, agranulocytosis, thrombocytopenia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain or discomfort.
General disorders and administration site conditions: Asthenia (parenteral). Rarely, fever.
Musculoskeletal and connective tissue disorders: Rarely, arthralgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Rarely, thromboembolism (parenteral).
Synthesis
Nowadays, the production methods of etamsylate in the market are benzoquinone method, in which benzoquinone method is to pass sulfur dioxide in the solution of diethylamine, ethanol and water, and then make diethylamine sulfite salt, then add p-benzoquino
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Etamsylate is excreted unchanged, mainly in the urine.
